PHYTOCHEMICAL ESTIMATION AND ANTIPARKINSON POTENTIAL OF ARTICUM LAPPA

• Author Information

  Ritu Rawat, Surbhi Jangir

  Department of Pharmacology, Jaipur College of Pharmacy, Jaipur, Rajasthan

• Ritu Rawat, Surbhi Jangir
• ESTIMATION AND ANTIPARKINSON

Abstract

Parkinson's disease (PD) is a complex, age-related neurodegenerative disease that causes neuronal loss and dysfunction over time. An imbalance of redox potential of oxidative stress in the cell causes neurodegenerative diseases and dysfunction of neurons. Plants are a rich source of bioactive substances that attenuate oxidative stress in a variety of neurological disorders. The study explored the anti-Parkinson potential of ethanolic extract from the roots of Articum lappa, attributing its efficacy to the high phenolic and flavonoid contents. Initial investigations involved the characterization of the plant’s physiochemical and phytochemical profile, revealing a diverse array of bioactive compounds. The findings suggest that the aqueous extract of Articum lappa exhibits significant antioxidant properties and promising effects in animal models of Parkinson's disease. This research highlights the need for further clinical studies and activity-guided fractionations to enhance our understanding and application of Articum lappa in the development of new herbal drugs. By advancing these research directions, the therapeutic potential of Articum lappa extracts could be fully realized, potentially leading to innovative treatments for Parkinson's disease and other neurodegenerative disorders. Keywords Parkinson's disease, Arctium lappa, Rotenone, Neurodegeneration, etc.