Phytochemistry, Botany, and Therapeutic Potentials of Withania coagulans: A Comprehensive Review

• Author Information

  Sugandha, Divya Singh, Smriti Rai, Bhartendra Singh Parmar

• Sugandha, Divya Singh, Smriti Rai, Bhartendra Singh Parmar
• Phytochemistry, Botany, and Therapeutic Potentials of Withania coagulans: A Comprehensive Review

Abstract

Herbal plants have long been used to manage and treat a wide range of health conditions. Ayurvedic medicine, in particular, remains important due to its minimal side effects and extensive therapeutic benefits. Withania coagulans (Family: Solanaceae), a highly valued medicinal plant, has traditionally been employed to treat abnormal cell growth, wasting disorders, neurological and physical ailments, diabetes mellitus, insomnia, and both acute and chronic liver diseases. This review offers a comprehensive overview of the phytochemistry, pharmacognosy, and biological activities of W. coagulans. The plant exhibits notable diuretic, anti-inflammatory, antibacterial, antifungal, cardioprotective, hepatoprotective, hypoglycemic, antioxidant, and antimutagenic effects, largely attributed to its rich content of withanolides. In addition, W. coagulans contains other important phytoconstituents such as flavonoids, tannins, and β-sterols. Evidence from multiple studies suggests that various plant parts and their bioactive compounds possess significant pharmacological and therapeutic potential, supporting the use of W. coagulans as a promising candidate for developing new treatments for diverse diseases.